In modern societies, sleep deprivation is a serious health problem. This problem could be induced by a variety of reasons, including lifestyle habits or neurological disorders. Chronic sleep deprivation (CSD) could have complex biological consequences, such as changes in neural autonomic control, increased oxidative stress, and inflammatory responses. The superior cervical ganglion (SCG) is an important sympathetic component of the autonomic nervous system. CSD can lead to a wide range of neurological consequences in SCG, which mainly supply innervations to circadian system and other structures. As the active component of Curcuma longa, curcumin possesses many therapeutic properties; including neuroprotective. This study aimed to evaluate the effect of CSD on the SCG histomorphometrical changes and the protective effect of curcumin in preventing these changes. Thirty-six male rats were randomly assigned to the control, curcumin, CSD, CSD + curcumin, grid floor control, and grid floor + curcumin groups. The CSD was induced by a modified multiple platform apparatus for 21 days and animals were sacrificed at the end of CSD or treatment, and their SCGs removed for stereological and TUNEL evaluations and also spatial arrangement of neurons in this structure. Concerning stereological findings, CSD significantly reduced the volume of SCG and its total number of neurons and satellite glial cells in comparison with the control animals (P < 0.05). Treatment of CSD with curcumin prevented these decreases. Furthermore, TUNEL evaluation showed significant apoptosis in the SCG cells in the CSD group, and treatment with curcumin significantly decreased this apoptosis (P < 0.01). This decrease in apoptosis was observed in all control groups that received curcumin. CSD also changed the spatial arrangement of ganglionic neurons into a random pattern, whereas treatment with curcumin preserved its regular pattern. CSD could potentially induce neuronal loss and structural changes including random spatial distribution in the SCG neurons. Deleterious effects of sleep deprivation could be prevented by the oral administration of curcumin. Furthermore, the consumption of curcumin in a healthy person might lead to a reduction of cell death.

中文翻译：

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在大鼠模型中，姜黄素可防止神经元丢失和慢性睡眠剥夺引起的上颈（交感神经）神经节结构改变。

在现代社会中，睡眠不足是一个严重的健康问题。可能由于多种原因引起此问题，包括生活方式习惯或神经系统疾病。慢性睡眠剥夺（CSD）可能具有复杂的生物学后果，例如神经自主控制的改变，氧化应激增加和炎症反应。颈上神经节（SCG）是植物神经系统的重要交感成分。CSD可导致SCG发生多种神经系统疾病，这主要为神经节律系统和其他结构提供神经。姜黄素作为姜黄的活性成分，具有许多治疗作用。包括神经保护作用。这项研究旨在评估CSD对SCG组织形态变化的影响以及姜黄素在预防这些变化方面的保护作用。将36只雄性大鼠随机分为对照组，姜黄素，CSD，CSD +姜黄素，格子底对照和格子底+姜黄素组。通过改良的多平台仪器诱导CSD持续21天，并在CSD或治疗结束时处死动物，并移除其SCG，以进行立体和TUNEL评估，并在此结构中调节神经元的空间。关于立体学发现，与对照动物相比，CSD显着减少了SCG的体积及其神经元和附属神经胶质细胞的总数（P <0.05）。用姜黄素治疗CSD可以防止这些下降。此外，TUNEL评估显示CSD组SCG细胞中存在明显的凋亡，姜黄素治疗显着降低了该凋亡（P <0.01）。在接受姜黄素的所有对照组中均观察到凋亡减少。CSD还将神经节神经元的空间排列改变为随机模式，而姜黄素治疗则保留了其规则模式。CSD可能会导致神经元丢失和结构变化，包括SCG神经元中的随机空间分布。口服姜黄素可以预防睡眠不足的有害影响。此外，在健康人中食用姜黄素可能会减少细胞死亡。在接受姜黄素的所有对照组中均观察到凋亡减少。CSD还将神经节神经元的空间排列改变为随机模式，而姜黄素治疗则保留了其规则模式。CSD可能会导致神经元丢失和结构变化，包括SCG神经元中的随机空间分布。口服姜黄素可以预防睡眠不足的有害影响。此外，在健康人中食用姜黄素可能会减少细胞死亡。在接受姜黄素的所有对照组中均观察到凋亡减少。CSD还将神经节神经元的空间排列改变为随机模式，而姜黄素治疗则保留了其规则模式。CSD可能会导致神经元丢失和结构变化，包括SCG神经元中的随机空间分布。口服姜黄素可以预防睡眠不足的有害影响。此外，在健康人中食用姜黄素可能会减少细胞死亡。CSD可能会诱发神经元丢失和结构变化，包括SCG神经元中的随机空间分布。口服姜黄素可以预防睡眠不足的有害影响。此外，在健康人中食用姜黄素可能会减少细胞死亡。CSD可能会导致神经元丢失和结构变化，包括SCG神经元中的随机空间分布。口服姜黄素可以预防睡眠不足的有害影响。此外，在健康人中食用姜黄素可能会减少细胞死亡。