Abstract

In people with young onset Parkinson’s disease (YOPD), onset of symptoms is between 21 and 40 years of age. The distinction between YOPD and late-onset Parkinson’s disease is supported by genetic differences (a genetic etiology is more common in people with YOPD) and clinical differences (e.g., dystonia and levodopa-induced dyskinesias are more common inYOPD). Moreover, people with YOPD tend to have different family and societal engagements compared to those with late-onset PD. These unique features have implications for clinical management, and call for a tailored multidisplinary approach involving shared-decision making.

中文翻译：

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年轻发作的帕金森病：一种现代和量身定制的方法。

摘要

在年轻发作的帕金森病 (YOPD) 患者中，症状出现在 21 至 40 岁之间。YOPD 和迟发性帕金森病之间的区别得到遗传差异（遗传病因在 YOPD 患者中更常见）和临床差异（例如，肌张力障碍和左旋多巴引起的运动障碍在 YOPD 中更常见）的支持。此外，与晚发型 PD 患者相比，YOPD 患者往往有不同的家庭和社会参与。这些独特的功能对临床管理有影响，并需要一种量身定制的多学科方法，包括共同决策。