In this study, a method was developed for examining the distribution pattern of inorganic substances dispersed in hydrogel-filled medical devices. Transmission electron microscopy (TEM) using ultra-thin cryosectioning (owing to hydrogel's water content) was performed on contact lenses with an iris pattern in which the distribution pattern of inorganic pigments was problematic. We confirmed the depth and distribution pattern of pigments in the hydrogel. The results indicated that ultra-thin cryosectioning with TEM was effective for inspecting the distribution of inorganic substances in hydrogel-filled devices.

中文翻译：

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使用超薄冷冻切片对医疗器械凝胶材料中分布的无机物质进行 TEM 观察

在这项研究中，开发了一种方法来检查分散在水凝胶填充的医疗器械中的无机物质的分布模式。使用超薄冷冻切片（由于水凝胶的含水量）的透射电子显微镜（TEM）对具有虹膜图案的隐形眼镜进行，其中无机颜料的分布图案存在问题。我们确认了水凝胶中颜料的深度和分布模式。结果表明，TEM 超薄冷冻切片可有效检查水凝胶填充装置中无机物质的分布。