In recent years non-classical models have emerged as mainstays for studies of evolutionary, developmental and regenerative biology. Genomic advances have promoted the use of alternative taxa for the study of developmental biology, and the shark is one such emerging model vertebrate. Our research utilizes the embryonic shark (Scyliorhinus canicula) to characterize key developmental and regenerative processes that have been overlooked or not possible to study with more classic developmental models. Tooth development is a major event in the construction of the vertebrate body plan, linked in part with the emergence of jaws. Early development of the teeth and morphogenesis is well known from the murine model, but the process of tooth redevelopment and regeneration is less well known. Here we explore the role of the dental lamina in the development of a highly regenerative dentition in sharks. The shark represents a polyphyodont vertebrate with continuously repeated whole tooth regeneration. This is presented as a major developmental shift from the more derived renewal process that the murine model offers, where incisors exhibit continuous renewal and growth of the same tooth. Not only does the shark offer a study system for whole unit dental regeneration, it also represents an important model for understanding the evolutionary context of vertebrate tooth regeneration.

中文翻译：

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牙板：鲨鱼永久牙齿再生的基本结构

近年来，非经典模型已成为进化、发育和再生生物学研究的支柱。基因组学的进步促进了替代类群在发育生物学研究中的使用，鲨鱼就是这样一种新兴的模式脊椎动物。我们的研究利用胚胎鲨鱼 (Scyliorhinus canicula) 来表征被忽视或无法用更经典的发育模型进行研究的关键发育和再生过程。牙齿发育是脊椎动物身体结构构建过程中的一件大事，部分与颌骨的出现有关。牙齿的早期发育和形态发生在小鼠模型中是众所周知的，但牙齿再发育和再生的过程却鲜为人知。在这里，我们探讨了牙板在鲨鱼高度再生牙列发展中的作用。鲨鱼代表了一种多齿脊椎动物，具有不断重复的全牙再生。这是从小鼠模型提供的更派生的更新过程的重大发展转变，其中门牙表现出同一颗牙齿的连续更新和生长。鲨鱼不仅为整体牙齿再生提供了一个研究系统，它还代表了理解脊椎动物牙齿再生进化背景的重要模型。其中门牙表现出同一颗牙齿的持续更新和生长。鲨鱼不仅为整体牙齿再生提供了一个研究系统，它还代表了理解脊椎动物牙齿再生进化背景的重要模型。其中门牙表现出同一颗牙齿的持续更新和生长。鲨鱼不仅为整体牙齿再生提供了一个研究系统，它还代表了理解脊椎动物牙齿再生进化背景的重要模型。