Impulsivity is a neuropsychiatric feature of Parkinson’s disease (PD). We investigated the pathophysiology of impulsivity in PD using resting-state functional magnetic resonance imaging (rs-fMRI). We investigated 45 patients with idiopathic PD and 21 healthy controls. Based on Barratt Impulsiveness Scale (BIS-11) score, PD patients were classified as higher (PD-HI) or lower impulsivity (PD-LI). Functional connectivity (FC) between various large-scale brain networks were analysed using the CONN toolbox. FC between the right frontoparietal network (FPN) and medial visual network (MVN) was significantly higher in PD-HI patients than PD-LI patients (false discovery rate [FDR]-adjusted p = 0.0315). FC between the right FPN and MVN had a significant positive correlation with total BIS-11 score (FDR-adjusted p = 0.010) and the attentional impulsivity (FDR-adjusted p = 0.046) and non-planning impulsivity subscale scores (FDR-adjusted p = 0.018). On the other hand, motor impulsivity subscale score had a significant negative correlation with the FC between the default-mode and salience networks (right supramarginal gyrus, FDR-adjusted p = 0.018; anterior cingulate cortex, FDR-adjusted p = 0.027); this trend was observed in healthy controls. The attentional and non-planning impulsivity, regarded as ‘cognitive’ impulsivity, may be associated with dysfunction in integration of perceptual information and flexible cognitive control in PD.

冲动是帕金森氏病（PD）的神经精神科特征。我们使用静止状态功能磁共振成像（rs-fMRI）研究了PD冲动的病理生理。我们调查了45例特发性PD患者和21例健康对照者。根据Barratt冲动量表（BIS-11）评分，将PD患者分为较高（PD-HI）或较低冲动（PD-LI）。使用CONN工具箱分析了各种大型大脑网络之间的功能连接（FC）。PD-HI患者的右额前额叶网络（FPN）和内侧视觉网络（MVN）之间的FC明显高于PD-LI患者（错误发现率[FDR]调整后的p  = 0.0315）。正确的FPN和MVN之间的FC与BIS-11总得分呈显着正相关（经FDR调整后p  = 0.010）和注意冲动（FDR调整后的p  = 0.046）和非计划冲动子量表得分（FDR调整后的p  = 0.018）。另一方面，运动冲动分量表评分与默认模式和显着网络之间的FC显着负相关（右上颌上回，FDR调整后的p  = 0.018；前扣带回皮层，FDR调整后的p  = 0.027）；在健康对照组中观察到了这种趋势。注意和非计划性冲动被视为“认知”冲动，可能与PD中知觉信息整合和灵活的认知控制功能障碍有关。