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Fluctuation X-ray diffraction reveals three-dimensional nanostructure and disorder in self-assembled lipid phases
Communications Materials Pub Date : 2020-07-10 , DOI: 10.1038/s43246-020-0044-z
Andrew V. Martin , Alexander Kozlov , Peter Berntsen , Francisco Gian Roque , Leonie Flueckiger , Saumitra Saha , Tamar L. Greaves , Charlotte E. Conn , Adrian M. Hawley , Timothy M. Ryan , Brian Abbey , Connie Darmanin

Emergent nanoscale order in materials such as self-assembled lipid phases, colloidal materials and metal-organic frameworks is often characterized by small-angle X-ray scattering (SAXS). Frequently, residual disorder in these materials prevents high-resolution 3D structural characterization. Here we demonstrate that angular intensity variations in SAXS patterns can provide previously inaccessible information about local 3D structure via a rich, real-space distribution of three- and four-body statistics. We present the many-body characterisation of a monoolein-based hexagonal phase doped with a phospholipid, revealing non-uniform curvature in the lipid channels, likely due to phase separation of the lipids in the membrane. Our many-body technique has general applicability to nanomaterials with order in the range 10 nm−1 μm currently targeted by synchrotron SAXS and has the potential to impact diverse research areas within chemistry, biology and materials science.



中文翻译:

波动X射线衍射揭示了自组装脂质相的三维纳米结构和无序

自组装脂质相,胶体材料和金属有机骨架等材料中出现的纳米级秩序通常以小角度X射线散射(SAXS)为特征。通常,这些材料中的残留混乱会阻止高分辨率3D结构表征。在这里,我们证明了SAXS模式中的角度强度变化可以通过三体和四体统计的丰富的实际空间分布提供有关局部3D结构的以前不可访问的信息。我们介绍了多磷脂的磷脂掺杂的单油基六方相的表征,揭示了在脂质通道中的曲率不均匀,这可能是由于膜中脂质的相分离所致。我们的多体技术普遍适用于顺序在10 nm -1范围内的纳米材料 μm目前被同步加速器SAXS定位,并且有可能影响化学,生物学和材料科学领域的各个研究领域。

更新日期:2020-07-10
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