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Tract-specific analysis improves sensitivity of spinal cord diffusion MRI to cross-sectional and longitudinal changes in amyotrophic lateral sclerosis.
Communications Biology ( IF 5.9 ) Pub Date : 2020-07-10 , DOI: 10.1038/s42003-020-1093-z
Pramod Kumar Pisharady 1, 2 , Lynn E Eberly 1, 3 , Ian Cheong 1 , Georgios Manousakis 4 , Gaurav Guliani 4 , H Brent Clark 5 , Mark Bathe 2 , David Walk 4 , Christophe Lenglet 1
Affiliation  

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease that causes progressive degeneration of motor neurons in the brain and the spinal cord. Corticospinal tract degeneration is a defining feature of ALS. However, there have been very few longitudinal, controlled studies assessing diffusion MRI (dMRI) metrics in different fiber tracts along the spinal cord in general or the corticospinal tract in particular. Here we demonstrate that a tract-specific analysis, with segmentation of ascending and descending tracts in the spinal cord white matter, substantially increases the sensitivity of dMRI to disease-related changes in ALS. Our work also identifies the tracts and spinal levels affected in ALS, supporting electrophysiologic and pathologic evidence of involvement of sensory pathways in ALS. We note changes in diffusion metrics and cord cross-sectional area, with enhanced sensitivity to disease effects through a multimodal analysis, and with strong correlations between these metrics and spinal components of ALSFRS-R.



中文翻译:

特定于运动的分析提高了脊髓扩散MRI对肌萎缩性侧索硬化症的横截面和纵向变化的敏感性。

肌萎缩性侧索硬化症(ALS)是一种迟发性致命性神经退行性疾病,可导致大脑和脊髓中运动神经元的进行性退化。皮质脊髓束变性是ALS的定义特征。然而,很少有纵向,对照研究评估一般沿脊髓或特别是皮质脊髓束在不同纤维束中的弥散MRI(dMRI)指标。在这里,我们证明了对特定区域的分析,以及脊髓白质中上升段和下降段的分割,大大提高了dMRI对ALS相关疾病变化的敏感性。我们的工作还确定了ALS中受影响的管道和脊柱水平,支持ALS感觉途径参与的电生理和病理学证据。

更新日期:2020-07-10
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