Frontiers in Genetics ( IF 3.7 ) Pub Date : 2020-06-11 , DOI: 10.3389/fgene.2020.00713 Bin Jiang 1 , Min Bi 1 , Jun Li 1 , Qi Liu 1 , Nai-An Xiao 1 , Jie Fang 1 , Man-Yi Shi 1 , Zi-Wen Yu 1 , Qi-Lin Ma 1 , Sui-Jun Tong 1 , Kun-Mu Zheng 1
Familial Alzheimer’s disease (FAD) present as a positive family history of cognitive decline, with early onset and an autosomal dominant inheritance pattern. FAD is mainly caused by the mutations in the genes encoding for amyloid precursor protein (