Gastrointestinal microbiota impact host's biological activities, including digestion of indigestible feed components, energy harvest, and immunity. In this study, fecal microbiota of high body weight (HW) and low body weight (LW) growing pigs at 103 days of age were compared. Principal coordinates analysis separated the HW and LW groups into two clusters, indicating their potential differences between microbial community composition. Although the abundances of two major phyla, Firmicutes and Bacteroidetes, did not significantly differ between the HW and LW groups, some genera showed significant differences. Among them, Peptococcus and Eubacterium exhibited strong positive correlations with body weight (BW) and average daily gain (ADG) (Rho > 0.40), whereas Treponema , Desulfovibrio , Parabacteroides , and Ruminococcaceae_unclassified exhibited strong negative correlations with BW and ADG (Rho < −0.40). Based on these results, the structure of intestinal microbiota may affect growth traits in pigs through host–microbe interactions. Further in‐depth studies will provide insights into how best to reshape host–microbe interactions in pigs and other animals as well.

中文翻译：

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生长猪体重与其肠道菌群功能之间的关联。

胃肠道微生物群影响宿主的生物活动，包括消化难消化的饲料成分、能量收集和免疫力。在这项研究中，比较了 103 日龄高体重 (HW) 和低体重 (LW) 生长猪的粪便微生物群。主坐标分析将 HW 和 LW 组分成两个簇，表明它们在微生物群落组成之间的潜在差异。尽管厚壁菌门和拟杆菌门这两个主要门的丰度在 HW 和 LW 组之间没有显着差异，但一些属显示出显着差异。其中，消化球菌和真杆菌与体重（BW）和平均日增重（ADG）呈强正相关（Rho > 0.40），而密螺旋体、Desulfovibrio、Parabacteroides和Ruminococcaceae_unclassified与 BW 和 ADG 表现出强烈的负相关性 (Rho < -0.40)。基于这些结果，肠道微生物群的结构可能通过宿主-微生物相互作用影响猪的生​​长特性。进一步的深入研究将为如何最好地重塑猪和其他动物的宿主-微生物相互作用提供见解。