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Adjusted multiple gases in the plasma flow induce differential antitumor potentials of plasma‐activated solutions
Plasma Processes and Polymers ( IF 3.5 ) Pub Date : 2020-07-10 , DOI: 10.1002/ppap.201900259
Kae Nakamura 1, 2 , Nobuhisa Yoshikawa 1 , Masato Yoshihara 1 , Yoshiki Ikeda 1 , Akihiro Higashida 3 , Akihiro Niwa 3 , Takahiro Jindo 3 , Hiromasa Tanaka 2, 4 , Kenji Ishikawa 2 , Masaaki Mizuno 4 , Shinya Toyokuni 2, 5 , Masaru Hori 2 , Fumitaka Kikkawa 1, 2 , Hiroaki Kajiyama 1
Affiliation  

We present a novel plasma system that can generate a plasma‐activated medium by changing the proportion of reactive gases such as oxygen, nitrogen, and hydrogen in the plasma flow. The correlation between the biological activity of plasma‐activated solutions prepared under multiple plasma gas‐flow conditions was evaluated. Mixed nitrogen, in addition to oxygen, in the gas flow is most powerful for producing plasma‐activated Ringer's lactate solution against antitumor effects on ovarian cancer cells as compared with oxygen or nitrogen alone. The antitumor effect of plasma‐activated solutions is controllable by the modification of the proportion of reactive gases (especially nitrogen and oxygen gases) in the plasma flow. These results suggest that the plasma flow conditions may be one of the candidates for the specifications of the plasma‐activated solutions to the therapeutic effect.

中文翻译:

调节血浆流中的多种气体会诱发血浆激活溶液的不同抗肿瘤电位

我们提出了一种新型的等离子体系统,该系统可以通过改变等离子体流中诸如氧气,氮气和氢气等反应性气体的比例来生成等离子体激活的介质。评价了在多种血浆气流条件下制备的血浆活化溶液的生物活性之间的相关性。与氧气或氮气相比,气流中除氧气外的混合氮气最能产生血浆活化的林格氏乳酸盐溶液,以对抗卵巢癌细胞的抗肿瘤作用。血浆活化溶液的抗肿瘤作用可通过改变血浆中反应气体(特别是氮气和氧气)的比例来控制。
更新日期:2020-07-10
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