The current work examined the outcome of curcumin (20 mg/kg body weight/day) administration on arginase and adenosine deaminase (ADA) activities and other kidney markers, as well as markers of oxidative stress, in Wistar rats exposed to sodium nitrite (NaNO₂) (60 mg/kg of body weight, single dose) for 28 days. The results revealed that the NaNO₂ exposed rats had significantly altered the ADA activities, arginase activities alongside other biomarkers of kidney function, and oxidative stress. However, pretreatment with curcumin significantly mitigated the altered activities ADA and arginase as well as other parameters. This was supported by the histopathological examination of the kidney tissues. Our findings suggest that the alteration in the activities of ADA and arginase could be involved in the mechanism of action employed by NaNO₂ and curcumin in the respective induction and prevention of nephrotoxicity.

中文翻译：

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姜黄素对抗亚硝酸钠诱导的雄性Wistar大鼠肾毒性的肾脏保护作用的潜在机制

目前的工作研究了在暴露于亚硝酸钠（NaNO）的Wistar大鼠中，姜黄素（20 mg / kg体重/天）施用精氨酸酶和腺苷脱氨酶（ADA）活性以及其他肾脏标志物以及氧化应激标志物的结果。₂）（60毫克/千克体重，单剂），持续28天。结果表明，NaNO ₂暴露的大鼠显着改变了ADA活性，精氨酸酶活性以及其他肾功能生物标志物和氧化应激。但是，用姜黄素预处理可显着减轻ADA和精氨酸酶活性以及其他参数的改变。肾脏组织的组织病理学检查证实了这一点。我们的发现表明，ADA和精氨酸酶活性的改变可能与NaNO ₂和姜黄素在各自诱导和预防肾毒性中所起作用的机制有关。