In order to gain information about the behavior of tin sulfide clusters with bio‐organic ligand shells under acidic conditions, such as found in undesirable cells for instance, we systematically treated amino acid‐functionalized tin sulfide clusters with different acids. For Boc‐protected amino acid derivatives, we could show that this treatment causes either cleavage of the protecting group of the amino acid or protolysis of the tin sulfide core under release of H₂S and formation of the correspondingly functionalized organotin trichloride, depending on the nature of the acid. This points towards a potential future use of such species for targeted cytotoxic applications.

中文翻译：

---

氨基酸官能化的硫化锡簇的质子分解

为了获得有关带有酸性条件下生物有机配体壳的硫化锡簇行为的信息（例如在不良细胞中发现的），我们用不同的酸系统地处理了氨基酸官能化的硫化锡簇。对于Boc保护的氨基酸衍生物，我们可以证明，这种处理会导致氨基酸保护基的裂解或在释放H ₂ S的情况下硫化锡核心发生质子分解，并形成相应官能化的有机三氯化锡，具体取决于酸的性质。这表明此类物种将来可能用于靶向细胞毒性应用。