Abstract Whereas that acute ruminal lactic acidosis (ARLA) can cause secondary metabolic disorders and some degree of cardiovascular damage, the present study aimed to evaluate the hemogasometry, concentrations of the creatine kinase isoenzyme MB (CKMB), cardiac troponin I (cTnI), and blood variables in goats with experimental ARLA. The disease was induced in five goats through intraruminal supply of 15 g sucrose/Kg live weight. Before induction and 4 h, 8 h, 12 h, 24 h, 48 h, 72 h, and 168 h post-induction (PI), clinical examination, ruminal fluid analysis, hemogasometry analysis, and measurement of AST, CK, CK-MB, cTnI, GGT, LDH, and l -lactate in the blood of these animals were performed. The experimental model used caused clinical alterations characteristic of ARLA in goats from 4 h PI. The characteristics of the ruminal fluid also changed from 4 h PI, becoming to milky appearance, acidic odor, aqueous consistency and a reduced population of protozoa. The ruminal pH decreased (P l -lactate (P = 0.0039) and LDH (P = 0.0005) and cTnI, CK-MB, CK, AST and GGT did not change (P> 0.05). Therefore, the evaluation of blood biochemistry aided in the monitoring of systemic changes resulting from ARLA in goats and the clinical condition induced by this experimental model did not cause cardiac injury.

中文翻译：

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实验性诱导急性瘤胃乳酸酸中毒山羊的血气测定、心脏生物标志物和血液代谢物

摘要 鉴于急性瘤胃乳酸酸中毒 (ARLA) 可导致继发性代谢紊乱和一定程度的心血管损伤，本研究旨在评估血气测定、肌酸激酶同工酶 MB (CKMB)、心肌肌钙蛋白 I (cTnI) 和实验性 ARLA 山羊的血液变量。通过瘤胃内供应 15 g 蔗糖/Kg 活重，在 5 只山羊中诱发了该疾病。诱导前和诱导后 4、8、12、24、48、72 和 168 小时（PI）、临床检查、瘤胃液分析、血气分析、AST、CK、CK-对这些动物的血液中的 MB、cTnI、GGT、LDH 和 l-乳酸进行了检测。使用的实验模型引起了山羊从 4 小时 PI 开始的 ARLA 的临床改变特征。瘤胃液的特征也从 PI 4 h 变为乳状，呈酸性气味，水性稠度和原生动物数量减少。瘤胃pH值降低（P l-乳酸（P = 0.0039）和LDH（P = 0.0005），cTnI、CK-MB、CK、AST和GGT没有变化（P> 0.05）。因此，血液生化的评估有帮助在监测山羊中 ARLA 引起的全身变化和由该实验模型引起的临床状况没有引起心脏损伤。