Nanoparticles are now widely used in various aspects of life, especially zinc oxide nanoparticles (ZnNPs) that used in mouth washing, cosmetics, sunscreens, toothpaste and root canal flings. This research aims to determine the impact of ZnNPs on healthy mice's brain tissue. ZnNPs have caused major changes in the brain monoamines (dopamine, norepinephrine and serotonin) and ions such as Ca²⁺, Na⁺, K⁺ and Zn²⁺. Concerning the histological picture, administration of ZnNPs caused some histopathological impairment in brain tissue. In addition, ZnNPs reduced the level of glutathione and catalase in brain tissue, although an increase in the level of nitrite / nitrate and ROS was observed, while the level of malondialdhyde was not significantly altered. Moreover, ZnNPs induced DNA fragmentation in brain of mice. Collectively, the obtained results revealed that ZnNPs affected the brain levels of investigated monamines, ions, enzymatic and non-enzymatic antioxidants thus they may have potential influence on central nervous system.

纳米粒子现已广泛应用于生活的各个方面，尤其是用于漱口水，化妆品，防晒霜，牙膏和牙根管的氧化锌纳米粒子（ZnNPs）。这项研究旨在确定ZnNPs对健康小鼠脑组织的影响。ZnNPs引起大脑单胺（多巴胺，去甲肾上腺素和血清素）和诸如Ca 2 ⁺，Na ⁺，K ⁺和Zn ^2+的离子发生了重大变化。。关于组织学图像，ZnNPs的使用引起了脑组织的一些组织病理学损害。另外，尽管观察到亚硝酸盐/硝酸盐和ROS的水平增加，但是ZnNPs减少了脑组织中谷胱甘肽和过氧化氢酶的水平，而丙二醛的水平没有显着改变。此外，ZnNPs诱导小鼠脑内DNA片段化。总的来说，获得的结果表明，ZnNPs影响所研究的单胺，离子，酶和非酶抗氧化剂的大脑水平，因此它们可能对中枢神经系统有潜在影响。