This study was performed to elucidate the uptake and bioaccumulation of polystyrene microplastics (PS-MPs) in Japanese medaka (freshwater fish) and Java medaka (marine fish), and to assess its impacts on the survival, reproduction, and gene expression of Japanese medaka. Both species were exposed to 2-μm fluorescent PS-MPs (10⁷ beads/L) for 3 weeks. The bioaccumulation factor of PS-MPs for Java medaka was calculated at about 4 × 10², higher than that for Japanese medaka (about 1 × 10²). The exposure had no significant effects on the survival and reproduction of Japanese medaka. The mRNA sequencing analysis showed that the expression of a few genes involved in the cell adhesion, xenobiotic metabolic process, brain development, and other functions in medaka intestines significantly changed after exposure. These results suggest that virgin PS-MPs can potentially accumulate in medaka intestines, but has limited toxicity to Japanese medaka at the concentration up to 10⁷ beads/L.

进行这项研究的目的是阐明日本（淡水鱼）和爪哇（海洋鱼）中聚苯乙烯微塑料（PS-MPs）的吸收和生物富集，并评估其对日本med的存活，繁殖和基因表达的影响。 。两种菌都暴露于2μm荧光PS-MP（10 ⁷珠/ L）中3周。计算出的Java medaka PS-MPs的生物积累因子约为4×10 ²，高于日本medaka的生物积累因子（约为1×10 ^2）。）。暴露对日本的存活和繁殖没有显着影响。mRNA测序分析表明，暴露后，与高粘肠细胞粘附，异种生物代谢过程，大脑发育及其他功能有关的一些基因的表达发生了显着变化。这些结果表明，原始的PS-MPs可能在高肠中积累，但在浓度高达10 ⁷珠/ L时对日本to具有有限的毒性。