In order to determine the potential of ^177mLu/¹⁷⁷Lu radionuclide generator in ¹⁷⁷Lu production it is important to establish the technical needs that can lead to a clinically acceptable ¹⁷⁷Lu product quality. In this work, a model that includes all the processes and the parameters affecting the performance of the ^177mLu/¹⁷⁷Lu radionuclide generator has been developed. The model has been based on the use of a ligand to complex ^177mLu ions, followed by the separation of the freed ¹⁷⁷Lu ions. The dissociation kinetics of the Lu-ligand complex has been found to be the most crucial aspect governing the specific activity and ^177mLu content of the produced ¹⁷⁷Lu. The dissociation rate constants lower than 1*10^-11 s^-1 would be required to lead to onsite ¹⁷⁷Lu production with specific activity close to theoretical maximum of 4.1 TBq ¹⁷⁷Lu/mg Lu and with ^177mLu content of less than 0.01%. Lastly, the calculations suggest that more than one patient dose per week can be supplied for a period of up to 7 months on starting with the ^177mLu produced using 3 g Lu₂O₃ target with 60% ¹⁷⁶Lu enrichment. The requirements of the starting ^177mLu activity production needs to be adapted depending on the required patient doses, and the technical specifications of the involved ^177mLu-¹⁷⁷Lu separation process.

为了确定¹⁷⁷ Lu生产中^{177 m} Lu / ¹⁷⁷ Lu放射性核素发生器的潜力，建立可导致临床上可接受的¹⁷⁷ Lu产品质量的技术需求非常重要。在这项工作中，开发了一个模型，其中包括影响^177m Lu / ¹⁷⁷ Lu放射性核素发生器性能的所有过程和参数。该模型基于使用配体络合^177m Lu离子，然后分离游离的¹⁷⁷ Lu离子的模型。现已发现，Lu-配体配合物的解离动力学是控制比活和活性的最关键方面。^177m Lu的含量产生了¹⁷⁷ Lu。低于1 * 10 ^-11 s ^-1的解离速率常数将导致现场产生¹⁷⁷ Lu，比活度接近理论最大值4.1 TBq ¹⁷⁷ Lu / mg Lu，^177m Lu含量小于0.01％。最后，计算表明从使用3 g Lu ₂ O ₃靶产生的^177m Lu（以60％¹⁷⁶ Lu富集的靶标）开始，每周最多可以提供7个月的患者剂量。对起点的要求^177m吕生产活动需要根据所需的患者的剂量进行调整，并且所涉及的技术规范^177米鲁¹⁷⁷个分离过程。