Hepatocellular carcinoma is characterized by the pronounced vascularization, high levels of vascular endothelial growth factors, and intensive angiogenesis. Caveola-mediated endocytosis and clathrin-dependent endocytosis contribute to internalization of various growth factors, thus affecting blood supply to the tumor and neoangiogenesis. We performed a quantitative analysis of blood vessels in the tumor and evaluated the basal levels of endocytosis-associated vesicular structures in the endothelial cells of the hepatocellular carcinoma-29. The numbers of blood vessels and clathrin-coated vesicles in endothelial cells in the tumor tissue were significantly higher than in normal tissue. The association between clathrin-dependent endocytosis in the endotheliocytes of the capillaries and tumor angiogenesis can provide the basis for the development of new molecular targets for antiangiogenic antitumor therapy.

中文翻译：

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肝细胞癌29毛细血管形态学分析及内皮细胞转运功能

肝细胞癌的特征在于明显的血管化、高水平的血管内皮生长因子和密集的血管生成。Caveola 介导的内吞作用和网格蛋白依赖性内吞作用有助于各种生长因子的内化，从而影响肿瘤的血液供应和新血管生成。我们对肿瘤中的血管进行了定量分析，并评估了肝细胞癌内皮细胞内吞作用相关囊泡结构的基础水平 - 29。肿瘤组织内皮细胞中血管和网格蛋白包被的囊泡数量明显高于正常组织。