The experiments on mice showed that subchronic food restriction to 40 and 8% of unrestricted ration is a strong stressor inducing devastation of lymphoid organs, primarily the thymus and spleen. The mice in the group with severe food restriction (8% of normal ration) demonstrated increased front paw grip force. We also observed an increase in spontaneous motor activity in these animals correlated with food restriction. Food deprivation led to inhibition of proliferative activity of the bone marrow cells and suppression of erythropoiesis. Moreover, severe food restriction was accompanied by a decrease in the number of double-strand DNA breaks evaluated by the release of γH2AX + -cells and the ratio of polychromatophilic erythrocytes.

中文翻译：

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食物限制小鼠的行为反应和免疫和细胞遗传学参数

小鼠实验表明，亚慢性食物限制在 40% 和 8% 的无限制日粮中是一种强烈的压力源，会导致淋巴器官（主要是胸腺和脾脏）的破坏。严重食物限制（正常口粮的 8%）组中的小鼠表现出增加的前爪抓地力。我们还观察到与食物限制相关的这些动物的自发运动活动增加。食物剥夺导致骨髓细胞增殖活性的抑制和红细胞生成的抑制。此外，严重的食物限制伴随着通过 γH2AX + - 细胞的释放和多嗜性红细胞的比率评估的双链 DNA 断裂数量的减少。