We studied the effects of Selank on the condition of the colon wall in Wistar male rats subjected to restraint stress. Selank was injected intraperitoneally in doses of 80, 250, and 750 μg/kg 15 min before stress exposure. In rats subjected to stress, signs of atrophy, inflammatory reaction, and changes in the number and functional activity of mast cells were observed against the background of increased corticosterone level. Selank administration led to a decrease in corticosterone levels, reduced pathomorphological manifestations of stress exposure, and accelerated adaptation. These effects were presumably realized due to multifunctional biological effects of Selank.

中文翻译：

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慢性束缚应激大鼠大肠形态学变化

我们研究了 Selank 对受到约束应激的 Wistar 雄性大鼠结肠壁状况的影响。在压力暴露前 15 分钟，以 80、250 和 750 μg/kg 的剂量腹膜内注射 Selank。在承受压力的大鼠中，在皮质酮水平升高的背景下，观察到萎缩迹象、炎症反应以及肥大细胞数量和功能活性的变化。Selank 给药导致皮质酮水平降低，减少应激暴露的病理形态学表现，并加速适应。这些效果可能是由于 Selank 的多功能生物效应而实现的。