We compared the direct neuroprotective effect of minor food components, antioxidants hesperetin and carnosine, and analyzed their influence on the parameters of the oxidative status of the penumbra zones in the cerebral cortex during focal ischemia (1 h) of with reperfusion in Wistar rats. The animals received hesperetin and carnosine included in the diet in daily doses of 50 and 150 mg/kg, respectively, for 7 days before ischemia induction. The neuroprotective effect of hesperetin manifested in reduction of the ischemic lesion size by 30%, which was comparable with the effect of carnosine. Both hesperetin and carnosine reduced the level of MDA in the penumbra zone of the cerebral cortex and increased the total antioxidant activity of the brain tissue. Hesperetin also increased SOD activity to a level observed in the sham-operated control group.

中文翻译：

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橙皮素和肌肽在大鼠脑局灶性缺血中的神经保护作用机制

我们比较了微量食物成分、抗氧化剂橙皮素和肌肽的直接神经保护作用，并分析了它们对 Wistar 大鼠再灌注局灶性缺血（1 小时）大脑皮层半暗带氧化状态参数的影响。在缺血诱导前 7 天，动物分别以 50 和 150 mg/kg 的日剂量接受饮食中包含的橙皮素和肌肽。橙皮素的神经保护作用表现为将缺血病灶大小减少 30%，这与肌肽的作用相当。橙皮素和肌肽都降低了大脑皮层半影区的 MDA 水平，并增加了脑组织的总抗氧化活性。橙皮素还将 SOD 活性增加到假手术对照组中观察到的水平。