Polymorphisms in the ESR1 gene have been associated with obesity and lipid metabolism. There are also important sex-related differences in the prevalence of obesity and related phenotypes. Therefore, we aimed to interrogate the association of the ESR1 rs2175898 gene polymorphism with obesity, obesity-related variables, and lipid levels in men and women as separate groups. Two thousand twenty-two randomly selected middle-aged and elderly Turks were genotyped for ESR1 rs2175898 polymorphism using real-time polymerase chain reaction with hybridization probes. We found sex-related differences of the ESR1 rs2175898 polymorphism in obesity. Logistic regression analysis after adjustment for age, smoking status, physical activity, diabetes mellitus, and the presence of menopause status in women demonstrated significantly decreased risk for obesity in female AG genotype carriers (OR 0.69; 95% CI 0.52–0.91; p = 0.010), and in male GG genotype carriers (OR 0.49; 95% CI 0.25–0.96; p = 0.039), Furthermore, carriers of the rs2175898 G allele exhibited a lower body mass index in both sexes and decreased waist circumference in women but not in men. Our findings also showed significantly higher serum total-C levels (p = 0.007) in the carriers of the AG+GG/AG genotype compared with the AA genotype in men. The AG genotype of the ESR1 rs2175898 polymorphism in women and GG genotype in men were found to have a decreased likelihood for obesity compared with the other rs2175898 genotypes.

ESR1基因的多态性与肥胖和脂质代谢有关。肥胖的患病率和相关表型也存在重要的性别相关差异。因此，我们旨在探究ESR1 rs2175898 基因多态性与肥胖、肥胖相关变量和男性和女性血脂水平之间的关联。使用实时聚合酶链反应和杂交探针对222名随机选择的中老年土耳其人进行了ESR1 rs2175898 多态性基因分型。我们发现ESR1 的性别相关差异rs2175898 肥胖症的多态性。调整年龄、吸烟状况、体力活动、糖尿病和女性更年期状态后的逻辑回归分析表明，女性 AG 基因型携带者的肥胖风险显着降低（OR 0.69；95% CI 0.52–0.91；p  = 0.010 )，并且在男性 GG 基因型携带者中（OR 0.49；95% CI 0.25–0.96；p  = 0.039），此外，rs2175898 G 等位基因携带者在两性中均表现出较低的体重指数和女性腰围减少，但在男人。我们的研究结果还显示， 与男性的 AA 基因型相比，AG+GG/AG 基因型携带者的血清总 C 水平显着更高（p = 0.007）。ESR1的 AG 基因型 与其他 rs2175898 基因型相比，女性的 rs2175898 多态性和男性的 GG 基因型肥胖的可能性降低。