Therapeutic potential of Prosopis cineraria has been extensively explored by many eminent researchers against various serious diseases but its activity against Lipopolysaccharide (endotoxin) is obscure. Therefore, present experimental investigation was conducted to unravel and analyze the anti-inflammatory potential of hydro-ethanol extract of Prosopis cineraria against LPS-induced inflammation in Swiss albino male mice. Swiss Albino male mice were intoxicated (intra-peritoneal) with LPS (2 mg/kg body weight) and further treated with low and high dose (i.e. 100 mg/kg body weight and 300 mg/kg body weight respectively) of hydro-ethanol extract of stem-bark of Prosopis cineraria. The levels of cytokines (TNF-α, Prostaglandins E2, IL-6, NF-κBp65, IFN-γ and IL-10) were determined in liver homogenate. Nitric oxide generated due to LPS-induced toxicity was estimated by using Griess reagent. The results demonstrated that the plant extract suppressed the over-expression and altered levels of cytokines due to LPS intoxication and restored the levels of TNF-α, NF-κB, NO, IL-6, IFN- γ, Prostaglandin E2 and IL-10. The present research work unravelled the alleviating potential of Prosopis cineraria against LPS-induced inflammation by modulating the expression of cytokines.

中文翻译：

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LPS诱导的小鼠模型中奇观树（Prosopis cineraria（L.）Druce）的茎皮的植物治疗潜力：抗炎研究

许多著名的研究人员已经广泛地探索了对Prosopis cineraria的治疗潜力，以对抗各种严重疾病，但是其对脂多糖（内毒素）的活性却不清楚。因此，进行了目前的实验研究，以揭示和分析瓜叶丙酸的乙醇提取物对LPS诱导的瑞士白化病雄性小鼠炎症的抗炎潜力。瑞士白化病雄性小鼠被LPS（2 mg / kg体重）中毒（腹膜内），并分别以低剂量和高剂量（即分别为100 mg / kg体重和300 mg / kg体重）的氢乙醇处理瓜叶Prosopis cineraria的茎皮提取物。测定肝匀浆中的细胞因子（TNF-α，前列腺素E2，IL-6，NF-κBp65，IFN-γ和IL-10）的水平。使用Griess试剂估算由于LPS诱导的毒性而产生的一氧化氮。结果表明，该植物提取物抑制了LPS中毒引起的细胞因子的过表达和水平改变，并恢复了TNF-α，NF-κB，NO，IL-6，IFN-γ，前列腺素E2和IL-10的水平。 。本研究工作通过调节细胞因子的表达，揭示了Prosopis cineraria对LPS诱导的炎症的缓解潜力。