The change in the benzodiazepine (BZD) use of patients with medically unexplained symptoms (MUS) following the application of relaxation therapy were examined. Of the 221 outpatients with MUS using BZD, 42 received relaxation therapy. Change in BZD use was compared using a relaxation group (n = 42) and a control group that had 84 MUS patients whose baseline was matched by optimal matching algorithms. Logistic regression analysis was done to evaluate the effect of BZD-dependent factors on the BZD dose of the relaxation group. Compared with the control group, the number of patients who decreased the amount of BZD and the number of patients whose subjective symptoms of MUS improved were significantly higher in the relaxation group (p < 0.05). In addition, a factor that made it difficult to reduce the BZD of MUS patients who had undergone relaxation was a long history of BZD use, for more than 6 months (odds ratio, 0.06, 95% confidence interval, 0.01–0.36). Relaxation therapy for patients with MUS may help reduce BZD use; however, early intervention is important to prevent BZD dependence.

中文翻译：

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放松疗法对医学上无法解释的症状患者使用苯二氮卓类药物的影响。

检查了应用放松疗法后有医学上无法解释的症状 (MUS) 的患者使用苯二氮卓 (BZD) 的变化。在使用 BZD 的 221 名 MUS 门诊患者中，42 名接受了放松疗法。使用放松组 (n = 42) 和对照组比较 BZD 使用的变化，对照组有 84 名 MUS 患者，其基线通过最佳匹配算法匹配。采用Logistic回归分析评价BZD依赖因素对放松组BZD剂量的影响。与对照组相比，放松组减少BZD用量的患者数量和改善MUS主观症状的患者数量显着高于对照组（p < 0.05）。此外，使放松的 MUS 患者的 BZD 难以降低的一个因素是长期使用 BZD，超过 6 个月（优势比，0.06，95% 置信区间，0.01-0.36）。MUS 患者的放松疗法可能有助于减少 BZD 的使用；然而，早期干预对于预防 BZD 依赖很重要。