当前位置:
X-MOL 学术
›
Org. Process Res. Dev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Optimization of a Decatungstate-Catalyzed C(sp3)–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2020-07-09 , DOI: 10.1021/acs.oprd.0c00235 Zhenghui Wen 1 , Apoorva Maheshwari 1 , Carlo Sambiagio 1 , Yuchao Deng 1, 2, 3 , Gabriele Laudadio 1 , Koen Van Aken 4, 5 , Yuhan Sun 2, 3 , Hannes P. L. Gemoets 4 , Timothy Noël 1
Organic Process Research & Development ( IF 3.4 ) Pub Date : 2020-07-09 , DOI: 10.1021/acs.oprd.0c00235 Zhenghui Wen 1 , Apoorva Maheshwari 1 , Carlo Sambiagio 1 , Yuchao Deng 1, 2, 3 , Gabriele Laudadio 1 , Koen Van Aken 4, 5 , Yuhan Sun 2, 3 , Hannes P. L. Gemoets 4 , Timothy Noël 1
Affiliation
Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C–H bonds. Using a recently developed oscillatory millistructured continuous-flow photoreactor, investigations of a decatungstate-catalyzed C(sp3)–H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.
中文翻译:
使用连续振荡的毫米结构光反应器,优化十碳酸盐催化的C(sp 3)–H烷基化反应
四丁基癸二酸铵(TBADT)已成为氢原子转移(HAT)过程的一种高效且多功能的光催化剂,可裂解活化的和未活化的脂肪族C–H键。使用最近开发的振荡的毫米结构连续流光反应器,对去catungstate催化的C(sp 3)–H烷基化方案已进行,结果在此处显示。与几个化学和工艺参数相关地评估了反应器的性能,包括停留时间,光强度,催化剂负载量和底物/试剂浓度。与以前报道的批处理和流动方案相比,发现条件可显着提高生产率,以高达7.5分钟的停留时间实现高达36.7 mmol / h的通量。
更新日期:2020-07-09
中文翻译:
使用连续振荡的毫米结构光反应器,优化十碳酸盐催化的C(sp 3)–H烷基化反应
四丁基癸二酸铵(TBADT)已成为氢原子转移(HAT)过程的一种高效且多功能的光催化剂,可裂解活化的和未活化的脂肪族C–H键。使用最近开发的振荡的毫米结构连续流光反应器,对去catungstate催化的C(sp 3)–H烷基化方案已进行,结果在此处显示。与几个化学和工艺参数相关地评估了反应器的性能,包括停留时间,光强度,催化剂负载量和底物/试剂浓度。与以前报道的批处理和流动方案相比,发现条件可显着提高生产率,以高达7.5分钟的停留时间实现高达36.7 mmol / h的通量。