Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the development of CRC. The results of bioinformatics analysis, immunohistochemical staining, and Western blot analysis showed that KIF20A was overexpressed in CRC tissues compared with adjacent normal tissues. High expression of KIF20A in CRC tissues was associated with depth of invasion, lymphatic node metastasis, distant metastasis, and TNM stage. Moreover, the Kaplan-Meier survival analysis showed that CRC patients with high KIF20A expression had poor prognoses. Cox regression analysis revealed that KIF20A was an independent prognostic factor in patients with CRC. Further studies suggested that knockdown of KIF20A was able to reduce cell proliferation and migration by inhibiting the JAK/STAT3 pathway. Taken together, we propose that KIF20A plays a critical role in the tumorigenesis and tumor progression of colorectal cancer and could represent a potential therapeutic target for CRC.

中文翻译：

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KIF20A 通过 JAK/STAT3 信号通路预测患者生存率不佳并促进结直肠癌肿瘤进展。

最近据报道，驱​​动蛋白家族成员 20A (KIF20A) 表达上调，并与多种恶性肿瘤的侵袭性和转移性增加相关。然而，KIF20A 在结直肠癌 (CRC) 中的作用仍不清楚。本研究旨在调查 KIF20A 在 CRC 发展中的潜在作用。生物信息学分析、免疫组化染色和Western blot分析结果表明，与癌旁正常组织相比，KIF20A在CRC组织中过表达。CRC组织中KIF20A的高表达与浸润深度、淋巴结转移、远处转移和TNM分期相关。此外，Kaplan-Meier生存分析显示，KIF20A高表达的CRC患者预后较差。Cox回归分析显示KIF20A是CRC患者的独立预后因素。进一步的研究表明，KIF20A 的敲低能够通过抑制 JAK/STAT3 通路来减少细胞增殖和迁移。综上所述，我们认为 KIF20A 在结直肠癌的肿瘤发生和肿瘤进展中发挥着关键作用，并且可能代表结直肠癌的潜在治疗靶点。