In this study, vapor phase deposition of quaternary ammonium polymers on different substrates was reported. Thin films of the poly(diethylaminoethyl methacrylate) (PDEAEMA) homopolymer and the poly(diethyl aminoethyl methacrylate-co-vinylbenzyl chloride) [P(DEAEMA-VBC)] copolymer were deposited by an initiated chemical vapor deposition (iCVD) technique using tert-butyl peroxide as an initiator. The variation of monomer feed ratios allowed control over the film structure. In the film structure, the tertiary amine group of DEAEMA is a key functionality behind the antibacterial activity, as verified after Fourier transform infrared spectroscopy and x-ray photoelectron spectroscopy analyses. The PDEAEMA homopolymer could be quaternized in a dry manner using an oxygen plasma treatment. The P(DEAEMA-VBC) copolymer, however, did not need an extra quaternization step because the tertiary amine group of the polymer could be readily quaternized by the chlorine moiety of the VBC unit. Both the homo- and copolymers exhibited high antibacterial activity on three different substrates, namely, glass, a polyethylene terephthalate sheet, and fabric. The antibacterial activity depended on the intensity of the quaternized nitrogen atoms in the as-deposited polymer. The adhesion and durability of the copolymer films were superior to that of the homopolymer film, verified using an adhesive tape peel-off test. The most durable copolymer film exhibited very high log-reduction values (>3) against gram-negative and gram-positive bacteria. Based on e cell viability analysis, the antibacterial films deposited by iCVD in this study were found to be nontoxic.

中文翻译：

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具有高抗菌活性的甲基丙烯酸季铵盐聚合物的气相沉积：合成路线，毒性评估和耐久性分析

在这项研究中，报道了季铵聚合物在不同基材上的气相沉积。聚甲基丙烯酸二乙氨基乙酯（PDEAEMA）均聚物和聚甲基丙烯酸二乙氨基乙酯-共乙烯基苄基氯[P（DEAEMA-VBC）]共聚物的薄膜通过叔胺的化学气相沉积（iCVD）技术沉积。过氧化丁基作为引发剂。单体进料比的变化允许控制薄膜结构。在膜结构中，DEAEMA的叔胺基团是抗菌活性背后的关键功能，这一点已通过傅立叶变换红外光谱和X射线光电子能谱分析进行了验证。PDEAEMA均聚物可以使用氧等离子体处理以干燥方式季铵化。但是，P（DEAEMA-VBC）共聚物 不需要额外的季铵化步骤，因为聚合物的叔胺基很容易被VBC单元的氯部分季铵化。均聚物和共聚物在三种不同的基材，即玻璃，聚对苯二甲酸乙二酯片和织物上均显示出高抗菌活性。抗菌活性取决于沉积聚合物中季铵化氮原子的强度。使用胶带剥离试验证实，共聚物膜的粘合性和耐久性优于均聚物膜。最耐用的共聚物薄膜对革兰氏阴性菌和革兰氏阳性菌表现出很高的对数减少值（> 3）。根据细胞活力分析，发现iCVD沉积的抗菌膜无毒。