Antigen escape by solid tumors has limited the efficacy of genetically modified T cells. T cells engineered to secrete the cytokine Flt3L induce the activation of endogenous T cells, enabling a broader repertoire of tumor antigens to be targeted via the expansion of intratumoral antigen presenting cells, significantly improving tumor responses.

中文翻译：

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工程T细胞在其靶标周围流动。

实体瘤的抗原逃逸限制了转基因T细胞的功效。经过工程改造以分泌细胞因子Flt3L的T细胞诱导内源性T细胞的活化，从而能够通过肿瘤内抗原呈递细胞的扩增来靶向更广泛的肿瘤抗原库，从而显着改善肿瘤反应。