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Systemic inflammation and dyslipidemia are associated with retinopathy in type 2 but not in type 1 diabetes.
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 2.1 ) Pub Date : 2020-07-09 , DOI: 10.1080/00365513.2020.1789921
Martina Tomić 1 , Romano Vrabec 1 , Sania Vidas Pauk 2 , Tomislav Bulum 3, 4 , Spomenka Ljubić 3, 4
Affiliation  

Abstract

The aim of this study was to investigate risk factors and role of systemic inflammation, dyslipidemia and obesity in development of diabetic retinopathy (DR) in type 1 and type 2 diabetes and determine the differences in risk factors between these two types of diabetes. Eighty-four type 1 and 107 type 2 diabetic patients were included in this cross-sectional study. Diabetes duration, body mass index (BMI) and waist-to-hip ratio (WHR) were assessed. C-reactive protein (CRP), fibrinogen (FIB), glycated hemoglobin (HbA1c), fasting and postprandial blood glucose (fBG, ppBG), HDL and LDL cholesterol and triglycerides (TG) were determined using routine methods. HbA1cmedian was obtained by statistical analysis of the CroDiabNet data and used as a marker of long-term glycemic control. Albumin excretion rate (AER) was measured in a 24-hour urine collection. Ophthalmologic retinal examination included indirect slit-lamp fundoscopy, color fundus photography according to EURODIAB (EUROpe and DIABetes) protocol and optical coherence tomography. DR was positively related to diabetes duration (p < .001), HbA1cmedian (p < .001) and AER (p = .008) in type 1, and diabetes duration (p < .001), HbA1cmedian (p = .018), AER (p < .001), CRP (p = .048) and TG (p = .041) in type 2 diabetes. Regression analysis showed that diabetes duration (OR 1.20, p = .005) and HbA1cmedian (OR 6.92, p = .007) were the main predictors of DR in type 1, and diabetes duration (OR 1.17, p < .001), fBG (OR 1.45, p = .024) and TG (OR 2.08, p = .025) in type 2 diabetes. In conclusion, systemic inflammation and dyslipidemia are associated with DR in type 2 but not in type 1 diabetes.



中文翻译:

全身炎症和血脂异常与 2 型糖尿病视网膜病变有关,但与 1 型糖尿病无关。

摘要

本研究的目的是调查全身炎症、血脂异常和肥胖在 1 型和 2 型糖尿病患者发生糖尿病视网膜病变 (DR) 中的危险因素和作用,并确定这两种糖尿病之间危险因素的差异。该横断面研究包括 84 名 1 型和 107 名 2 型糖尿病患者。对糖尿病病程、体重指数 (BMI) 和腰臀比 (WHR) 进行了评估。使用常规方法测定C 反应蛋白 (CRP)、纤维蛋白原 (FIB)、糖化血红蛋白 (HbA 1 c)、空腹和餐后血糖 (fBG、ppBG)、HDL 和 LDL 胆固醇和甘油三酯 (TG)。HbA 1 c中位数通过对 CroDiabNet 数据进行统计分析获得,并用作长期血糖控制的标志。在 24 小时尿液收集中测量白蛋白排泄率 (AER)。眼科视网膜检查包括间接裂隙灯眼底镜检查、根据 EURODIAB(EUROpe 和 DIABetes)协议的彩色眼底照相和光学相干断层扫描。DR 与 1 型糖尿病病程 ( p  < .001)、HbA 1 c中位数( p  < .001) 和 AER ( p  = .008) 以及糖尿病病程 ( p  < .001)、 HbA 1 c中位数呈正相关( p  = .018), AER ( p  < .001), CRP ( p = .048) 和 TG ( p  = .041) 在 2 型糖尿病中。回归分析显示糖尿病病程 (OR 1.20, p  = .005) 和 HbA 1 c中位数(OR 6.92, p  = .007) 是 1 型 DR 和糖尿病病程 (OR 1.17, p  < .001 ) 的主要预测因素)、fBG (OR 1.45, p  = .024) 和 TG (OR 2.08, p  = .025) 在 2 型糖尿病中。总之,全身炎症和血脂异常与 2 型糖尿病的 DR 相关,但与 1 型糖尿病无关。

更新日期:2020-07-09
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