Purpose

To evaluate the effect of photodynamic therapy and/or intravitreal injections on choroidal neovascularization in treatment-naïve patients affected by Best Macular Dystrophy using OCT-A

Materials and Methods

BMD patients with CNV treated using PDT and/or IV were included in the study. All patients underwent a complete ophthalmological examination, OCT and 3 × 3 mm OCT-A. The OCT-A images were analyzed using an open-source software (ImageJ) to assess the CNV membrane area (CNV-MA), the CNV vessel area (CNV-VA), and vessel density (VD) at the follow-ups (3 months after PDT and 1 month after IV).

Results

Five eyes of four patients with CNV were included. All eyes received PDT as first-line therapy; 4 eyes underwent more than 1 treatment session: three eyes received 1 IV, whereas one eye had one further PDT. After PDT, the CNV-MA, CNV-VA, and VD quantitative parameters were obtained for four out of five eyes: in three eyes of two patients CNV-MA, CNV-VA, and VD first decreased and then gradually increased during follow-up, whereas in one eye of one patient CNV-MA, CNV-VA, and VD slightly increased. After IV the CNV-MA, CNV-VA, and VD had significantly decreased at the 1-month follow-up in three eyes of three patients.

Conclusion

OCT-A is an important tool for the diagnosis of both naïve and fibrotic CNV in BMD patients; it is a non-invasive method for the qualitative and quantitative analysis of neovascular lesions during follow-up. Our results have shown a cyclic remodeling of treated CNV in BMD patients using both PDT and IV.

中文翻译：

---

最佳黄斑营养不良患者的CNV光学相干断层扫描血管造影循环重塑。

目的

使用OCT-A评估光动力疗法和/或玻璃体内注射对未接受过最佳黄斑营养不良的初治患者脉络膜新生血管的影响

材料和方法

使用PDT和/或IV治疗的CNV BMD患者被纳入研究。所有患者均接受了完整的眼科检查，OCT和3×3 mm OCT-A。使用开放源代码软件（ImageJ）分析OCT-A图像，以评估后续随访中的CNV膜面积（CNV-MA），CNV血管面积（CNV-VA）和血管密度（VD）（ PDT后3个月和IV后1个月）。

结果

包括四名CNV患者的五只眼。所有的眼睛都接受PDT作为一线治疗；4眼接受了1次以上的治疗：3眼接受了1次IV治疗，而另一只眼接受了另一次PDT。PDT后，五只眼中有四只获得了CNV-MA，CNV-VA和VD定量参数：在两名患者的三只眼中，CNV-MA，CNV-VA和VD在随访期间先降低​​然后逐渐升高上升，而在一名患者的一只眼睛中，CNV-MA，CNV-VA和VD略有增加。静脉注射后，三名患者的三只眼在1个月的随访中CNV-MA，CNV-VA和VD明显降低。

结论

OCT-A是诊断BMD患者初次和纤维化CNV的重要工具；这是一种在随访过程中对新血管病变进行定性和定量分析的非侵入性方法。我们的研究结果表明，PDT和IV均可治疗BMD患者CNV的周期性重塑。