ABSTRACT

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed protein that contains both an ion channel and an active kinase. TRPM7 has involved in a variety of cellular functions and critically participates in various diseases mainly including cancer and neurodegenerative disorders. However, the theme trends and knowledge structures for TRPM7 have not yet been studied bibliometrically. The main purposes of this research are to compare the scientific production in the research field of TRPM7 among countries and to evaluate the publication trend between 2004 and 2019. All publications were extracted from the Web of Science Core Collection (WoSCC) database from 2004 to 2019. Microsoft Excel 2018, Prism 6, and CiteSpace V were applied to analyze the scientific research outputs including journals, countries, territories, institutions, authors, and research hotspots. In this report, a total of 860 publications related to TRPM7 were analyzed. Biophysical Journal ranked top for publishing 31 papers. The United States of America had the largest number of publications (320) with a high citation frequency (11,298) and H-index (58). Chubanov V (38 publications) and Gudermann T (38 citations), who from Ludwig Maximilian University of Munich, were the most productive authors and had the greatest co-citation counts. Our study also combined the bibliometric study with a systematic review on TRPM7, highlighting the four research frontiers of TRPM7. This is the first study that demonstrated the trends and future development in TRPM7 publications, providing a clear and intuitive profile for the contributions in this field.

摘要

瞬时受体电位褪黑素亚家族成员 7 (TRPM7) 是一种普遍表达的蛋白质，包含离子通道和活性激酶。TRPM7参与多种细胞功能，并关键参与多种疾病，主要包括癌症和神经退行性疾病。然而，TRPM7的主题趋势和知识结构尚未得到文献计量研究。本研究的主要目的是比较各国TRPM7研究领域的科学成果，并评估2004年至2019年的出版趋势。所有出版物均摘自Web of Science核心合集（WoSCC）数据库2004年至2019年应用Microsoft Excel 2018、Prism 6和CiteSpace V对科研成果进行分析，包括期刊、国家、地区、机构、作者和研究热点。本报告共分析了 860 篇与 TRPM7 相关的出版物。《Biophysical Journal》以发表 31 篇论文位居榜首。美利坚合众国的出版物数量最多（320 篇），引用频率高（11,298 篇），H 指数高（58 篇）。来自慕尼黑路德维希马克西米利安大学的 Chubanov V（38 篇出版物）和 Gudermann T（38 次引用）是最多产的作者，并且拥有最多的共同被引次数。我们的研究还将文献计量研究与TRPM7的系统综述相结合，突出了TRPM7的四个研究前沿。这是第一项展示 TRPM7 出版物趋势和未来发展的研究，为该领域的贡献提供了清晰直观的概况。