This study was aimed to examine the possible underlying cardioprotective efficacy of tangeretin (TAN) in rats exposed to isoproterenol (ISP). Forty male SD rats were separated into four equal groups as the control group, ISP (myocardial infarction; MI group) group rats which were injected intraperitoneally (ip) with 85 mg/kg of ISP. Treatment TAN groups (TAN 50 and TAN 100) rats were orally pretreated with TAN (50 or 100 mg/kg) for 28 days before ISP exposure. Pretreatment with TAN (50/100) significantly reduced (p < .05/0.01) the infarct size, levels of inflammatory markers, cardiac marker enzymes, apoptotic markers along with improved antioxidants. Histo‐morphological results also well‐supported the results of the above biochemical parameters by displaying normal myofibrillar arrangement in TAN pretreated rats. Moreover, the protein expressions of pPI3K and pAkt were considerably elevated in rats administered with TAN. Collectively, TAN pretreatment (especially TAN 100) display better cardioprotective activity against ISP‐induced MI rats.

中文翻译：

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桔皮素对异丙肾上腺素的心脏保护作用背后的潜在潜在机制是通过调节大鼠模型中的PI3K / Akt信号传导途径触发心脏毒性的。

这项研究的目的是检查坦格列汀（TAN）在暴露于异丙肾上腺素（ISP）的大鼠中可能的潜在心脏保护作用。将40只雄性SD大鼠分为四个相等的组，作为对照组，即ISP（心肌梗塞； MI组）组大鼠，其腹膜内（ip）注射85mg / kg的ISP。在ISP暴露之前，对TAN组（TAN 50和TAN 100）大鼠进行TAN（50或100 mg / kg）口服预处理28天。TAN（50/100）预处理显着减少了（p <.05 / 0.01）梗死面积，炎性标志物水平，心脏标志物酶，凋亡标志物以及改良的抗氧化剂。通过在TAN预处理的大鼠中显示正常的肌原纤维排列，组织形态学结果也很好地支持了上述生化参数的结果。而且，在给予TAN的大鼠中，pPI3K和pAkt的蛋白表达显着升高。总的来说，TAN预处理（尤其是TAN 100）对ISP诱导的MI大鼠表现出更好的心脏保护活性。