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PR‐domain containing protein 12 ( prdm12 ) is a downstream target of transcription factor zic1 during cellular differentiation in central nervous system
International Journal of Developmental Neuroscience ( IF 1.8 ) Pub Date : 2020-09-03 , DOI: 10.1002/jdn.10048
Md Mahfujur Rahman 1, 2 , In-Shik Kim 1 , Dongchoon Ahn 1 , Hyun-Jin Tae 1 , Byung-Yong Park 1
Affiliation  

Transcription factor zic1 is an important regulator of neural plate patterning, formation of neural crest and cerebellar development, where its main function is neuronal cell differentiation. Among the genes identified, PR domain‐containing 12 (prdm12) is a member of the prdm family and is expressed in the placode domain in the neurula stage. prdm12 is distinctly expressed in the dorsal part of the midbrain, trigeminal ganglion, and the motor neuron in the spinal cord. prdm12 knockdown results in the ventralization of the neural tube. zic1 knockdown results in the reduction of prdm12 expression in the midbrain, motor neuron and trigeminal ganglion, and overexpression of zic1 results in the expansion of prdm12 expression in the midbrain. zic1‐activated wnt signaling is also a regulator of prdm12 expression in the midbrain. We propose that prdm12 is the downstream of zic1 and a novel player in the gene regulatory network controlling brain cell differentiation, along with some ganglions in Xenopus.

中文翻译:

含有 PR 结构域的蛋白 12 (prdm12) 是中枢神经系统细胞分化过程中转录因子 zic1 的下游靶标

转录因子 zic1 是神经板模式、神经嵴形成和小脑发育的重要调节因子,其主要功能是神经元细胞分化。在鉴定的基因中,含有 PR 结构域的 12 (prdm12) 是 prdm 家族的成员,在神经元阶段的基板结构域中表达。prdm12 在中脑的背侧部分、三叉神经节和脊髓中的运动神经元中明显表达。prdm12 敲低导致神经管腹侧化。zic1 敲低导致中脑、运动神经元和三叉神经节中 prdm12 表达的减少,而 zic1 的过度表达导致中脑中 prdm12 表达的扩大。zic1 激活的 wnt 信号也是中脑 prdm12 表达的调节器。
更新日期:2020-09-03
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