当前位置: X-MOL 学术Neuroscience › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Social Defeat Stress in Adolescent Mice Induces Depressive-like Behaviors with Reduced Oligodendrogenesis.
Neuroscience ( IF 3.3 ) Pub Date : 2020-07-09 , DOI: 10.1016/j.neuroscience.2020.07.002
Takeshi Shimizu 1 , Akimasa Ishida 1 , Mutsumi Hagiwara 1 , Yoshitomo Ueda 1 , Atsunori Hattori 1 , Naoki Tajiri 1 , Hideki Hida 1
Affiliation  

Strong stress related to adverse experiences during adolescence can cause mental disorders, as well as affecting brain structure and function. However, the underlying neurobiological mechanisms remain largely unknown. To investigate whether stress induced by adverse experience during adolescence affects oligodendrocyte (OL) remodeling, social defeat stress was applied to 6-week-old adolescent mice for 10 days, followed by behavioral tests and assessments of oligodendrogenesis. Socially defeated mice showed depressive-like behaviors in behavioral experiments. Stress led to a decrease in the number of newly born OLs in the anterior cortical region and the number of proteolipid protein-positive mature OLs in the corpus callosum and posterior cerebral cortex. Fewer bromodeoxyuridine-incorporated CC1-positive mature OLs were observed in these regions in socially defeated mice. To assess whether decreased oligodendrogenesis caused by social defeat stress is related to depressive-like symptoms under stress, clemastine, a drug that induces OL generation, was administered to socially defeated adolescent mice, resulting in the rescue of the behavioral abnormalities accompanied by increased oligodendrogenesis. These findings suggest that oligodendrogenesis in adverse environments during adolescence plays a role in psychiatric disorders, and clemastine may provide a potential therapeutic drug for adolescent mental disorders, targeting OLs.



中文翻译:

在青春期小鼠中的社交挫折压力诱导抑郁症样行为,减少少突胶质生成。

与青春期不良经历相关的强烈压力会导致精神错乱,并影响大脑的结构和功能。然而,基本的神经生物学机制仍然很大程度上未知。为了研究青春期不良经历所引起的压力是否影响少突胶质细胞(OL)的重塑,将社交失败压力应用于6周大的青春期小鼠10天,然后进行行为测试和评估少突胶质生成。在行为实验中,被社会击败的小鼠表现出类似抑郁的行为。压力导致前皮质区域的新生OL数量减少,call体和大脑后皮质的蛋白脂蛋白阳性成熟OL数量减少。在这些区域中,在社交能力较弱的小鼠中观察到较少的掺入溴脱氧尿苷的CC1阳性成熟OL。为了评估社交挫败压力引起的少突胶质生成是否与压力下的抑郁样症状相关,向社交挫败的青春期小鼠施用了clemastine(一种诱导OL生成的药物),从而挽救了伴随异常少突胶质生成的行为异常。这些发现表明,青春期不良环境中的少突胶质形成在精神疾病中起作用,而clemastine可能提供针对OLs的青春期精神疾病的潜在治疗药物。一种可以诱导OL产生的药物被用于在社会上受到挫败的青春期小鼠身上,从而挽救了伴随异常少突胶质生成的行为异常。这些发现表明,青春期不良环境中的少突胶质形成在精神疾病中起作用,而clemastine可能提供针对OLs的青春期精神疾病的潜在治疗药物。一种可以诱导OL产生的药物被用于在社会上受到挫败的青春期小鼠身上,从而挽救了伴随异常少突胶质生成的行为异常。这些发现表明,青春期不良环境中的少突胶质形成在精神疾病中起作用,而clemastine可能提供针对OLs的青春期精神疾病的潜在治疗药物。

更新日期:2020-07-09
down
wechat
bug