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Porphyrinoid Drug Conjugates
Chem ( IF 23.5 ) Pub Date : 2020-07-09 , DOI: 10.1016/j.chempr.2020.06.019
Jonathan F Arambula 1, 2 , Jonathan L Sessler 1
Affiliation  

Drawing inspiration from nature today remains a time-honored means of discovering the therapies of tomorrow. Porphyrins, the so-called “pigments of life” have played a key role in this effort due to their diverse and unique properties. They have seen use in a number of medically relevant applications, including the development of so-called drug conjugates wherein functionalization with other entities is used to improve efficacy while minimizing dose limiting side effects. In this Perspective, we highlight opportunities associated with newer, completely synthetic analogs of porphyrins, commonly referred to as porphyrinoids, as the basis for preparing drug conjugates. Many of the resulting systems show improved medicinal or site-localizing properties. As befits a Perspective of this type, our efforts to develop cancer-targeting, platinum-containing conjugates based on texaphyrins (a class of so-called “expanded porphyrins”) will receive particular emphasis; however, the promise inherent in this readily generalizable approach will also be illustrated briefly using two other common porphyrin analogs, namely the corroles (a “contracted porphyrin”) and porphycene (an “isomeric porphyrin”).



中文翻译:

卟啉类药物结合物

今天从大自然中汲取灵感仍然是发现明天疗法的一种古老的手段。卟啉,即所谓的“生命色素”,由于其多样而独特的特性而在这项工作中发挥了关键作用。他们已经在许多医学上相关的应用中看到了用途,包括开发所谓的药物缀合物,其中使用与其他实体的功能化来改善功效,同时使剂量限制副作用最小化。在本《观点》中,我们着重介绍了与新型,完全合成的卟啉类似物(通常称为卟啉类)相关的机会,以此作为制备药物偶联物的基础。许多所得系统显示出改进的医学或位点定位特性。根据这种观点,我们为开发针对癌症的目标而努力,基于texaphyrins(一类所谓的“扩展卟啉”)的含铂结合物将受到特别重视;然而,使用两种其他常见的卟啉类似物,即:corroles(一种“缩合卟啉”)和porphycene(一种“异构卟啉”),还将简要说明这种易于推广的方法固有的前景。

更新日期:2020-07-09
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