The biomolecule DNA with the presence of different functionalities found to interact with different kinds of metal ions and show relatively higher stability over a long period of time when optimized appropriately. With the presence of A-T and G-C pairs, sugar moieties, phosphate functional groups and the double-helical structure, it can assemble both cationic and anionic species and forms a perfect metal-DNA self-assembly. Depending upon the aspect ratio of metal-DNA self-assemblies, metal content and their morphological outcomes, they could deliver variance in the catalytic activities. Such differences can be brought out by varying the synthesis reaction parameters focusing on a specific electrocatalytic application. In this review, recent developments in DNA metallization is elaborated first highlighting the underlying interactions between DNA and cationic/anionic species of various metals following which application of metal-DNA assemblies in electrocatalytic water oxidation and reduction are discussed critically. Knowledge provided in this review thus acts as the guide to various DNA metallization strategies and their subsequent application to water electrolysis for hydrogen generation.

当进行适当优化时，发现具有不同功能的生物分子DNA与不同种类的金属离子相互作用，并在较长的时间内显示出较高的稳定性。在存在AT和GC对，糖部分，磷酸酯官能团和双螺旋结构的情况下，它可以组装阳离子和阴离子物质，并形成完美的金属DNA自组装。根据金属-DNA自组装体的长宽比，金属含量及其形态结果，它们可能在催化活性方面产生差异。可以通过改变针对特定电催化应用的合成反应参数来产生这种差异。在这篇评论中 详细阐述了DNA金属化的最新进展，首先着重强调了DNA与各种金属的阳离子/阴离子物种之间的潜在相互作用，然后重点讨论了金属DNA组装体在电催化水氧化和还原中的应用。因此，本综述中提供的知识可作为各种DNA金属化策略及其在水电解中生成氢的后续应用的指南。