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An Overview on Analytical Methods for Quantitative Determination of Aristolochic Acids
Current Analytical Chemistry ( IF 1.8 ) Pub Date : 2020-07-31 , DOI: 10.2174/1573411014666180704124213
Mohammad-Reza Afshar-Mogaddam 1 , Adeleh Yadeghari 2 , Abolghasem Jouyban 3
Affiliation  

Background: Aristolochic acids are chemically linked to nitrophenanthrene carboxylic acids which are found in aristolochia plants. These compounds are intrinsically carcinogenic, while they have been used in traditional medicine from a long time ago. Despite the beneficial effects of herbals for treating some diseases, they possess some side effects.

Methods: Therefore, the development of a sensitive and selective procedure for the determination of these harmful components in various complicated samples is an important task for health systems and drug authorities. In the past years, ultra-pressure liquid chromatography, high performance liquid chromatography and capillary electrophoresis with different detection systems were used for determination of aristolochic acids in various samples.

Results: In this review, different analytical methods have been discussed in brief and applications of them in diverse samples have been summarized.

Conclusion: Different approaches are compared from point of sensitivity, selectivity, and extraction efficiency.



中文翻译:

马兜铃酸定量分析方法概述

背景:马兜铃酸与在马兜铃植物中发现的硝基菲羧酸化学连接。这些化合物本质上具有致癌性,而很久以前它们已在传统医学中使用。尽管草药对治疗某些疾病有有益的作用,但它们仍具有一些副作用。

方法:因此,开发一种灵敏且选择性的程序来测定各种复杂样品中的这些有害成分是卫生系统和药物管理局的重要任务。近年来,使用超高压液相色谱法,高效液相色谱法和具有不同检测系统的毛细管电泳法测定各种样品中的马兜铃酸。

结果:在这篇综述中,简要讨论了不同的分析方法,并总结了它们在不同样品中的应用。

结论:从灵敏度,选择性和提取效率的角度比较了不同的方法。

更新日期:2020-07-31
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