Conjugation of drugs to polymers is a widely used approach to gain control over the release of therapeutics. In this contribution, salicylic acid, a multipurpose model drug, is conjugated to the biocompatible poly(2-ethyl-2-oxazoline) (PEtOx). The drug is attached to the side chains of a polymer carrier through a hydrolytically cleavable ester linker, via a sequential postpolymerization modification. The chemical modulation of this ester, i.e., by primary or secondary alcohols, is demonstrated to greatly influence the ester hydrolysis rate. This crucial parameter allows us to tune the in vitro kinetics of the sustained drug release for periods exceeding a month in phosphate-buffered saline (PBS). The synthetic accessibility of the cleavable linker, together with the modularity of the drug release rate offered by this approach, highlights the utility of this class of polymers in the field of long-lasting drug delivery systems for persistent and chronic disease treatment.

中文翻译：

---

聚（2-乙基-2-恶唑啉）通过可降解的模块化酯键与水杨酸结合。

药物与聚合物的结合是一种广泛使用的方法，可以控制治疗剂的释放。在这一贡献中，水杨酸（一种多功能模型药物）与生物相容性聚（2-乙基-2-恶唑啉）（PEtOx）偶联。药物通过连续的后聚合修饰，通过可水解裂解的酯连接基连接到聚合物载体的侧链上。已证明该酯的化学调节，即被伯或仲醇的化学调节极大地影响了酯的水解速率。这个关键参数使我们能够在体外进行调节在磷酸盐缓冲盐水（PBS）中持续药物释放超过一个月的动力学。可裂解接头的合成可及性，以及这种方法所提供的药物释放速率的模块化，突出了这类聚合物在持久药物输送系统领域中对持续和慢性疾病治疗的实用性。