Blood mitochondrial DNA levels remain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero.,The Journal of Infectious Diseases

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Blood mitochondrial DNA levels remain elevated from birth to early life in children HIV-exposed uninfected exposed to combination antiretroviral therapy in utero.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-07-08 , DOI: 10.1093/infdis/jiaa410
Abhinav Ajaykumar _{1,

2} , Mayanne Zhu ₁ , Fatima Kakkar ₃ , Jason Brophy ₄ , Ari Bitnun ₅ , Ariane Alimenti _{6,

7} , Hugo Soudeyns _{8,

9} , Sara Saberi _{1,

2} , Arianne Y K Albert ₁₀ , Deborah M Money _{7,

10,

11} , Hélène C F Côté _{1,

2,

10} ,

Affiliation

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.
Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, Quebec, Canada.
Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
BC Women's Hospital and Health Centre, Vancouver, British Columbia, Canada.
Unité d'Immunopathologie Virale, Centre de Recherche du CHU Sainte-Justine, Montreal, Quebec, Canada.
Department of Microbiology, Infectiology & Immunology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Women's Health Research Institute, Vancouver, British Columbia, Canada.
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.

Combination antiretroviral therapy (cART) during pregnancy prevents vertical transmission, but many antiretrovirals cross the placenta and several can affect mitochondria. Exposure to maternal HIV and/or cART could have long-term effects on children HIV-exposed uninfected (CHEU). Our objective was to compare blood mitochondrial DNA (mtDNA) content in CHEU and children HIV-unexposed uninfected (CHUU), at birth and in early life.

中文翻译：

在未感染 HIV 的儿童中，在子宫内接受联合抗逆转录病毒治疗的儿童从出生到生命早期，血液中的线粒体 DNA 水平一直处于升高状态。

怀孕期间的联合抗逆转录病毒疗法 (cART) 可防止垂直传播，但许多抗逆转录病毒药物会穿过胎盘，其中一些会影响线粒体。暴露于母亲 HIV 和/或 cART 可能对未感染 HIV 的儿童 (CHEU) 产生长期影响。我们的目标是比较 CHEU 和未暴露于 HIV 的儿童 (CHUU) 在出生时和生命早期的血液线粒体 DNA (mtDNA) 含量。

更新日期：2020-07-08

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