Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH₃) reduction of a nitrile bearing a CF₃ group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.

中文翻译：

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Alane（AlH ₃）还原带有CF _3基团的腈的大规模制备胺的过程中发生严重爆炸

在此，我们希望报告在通过烷烃（AlH ₃）还原带有CF ₃基团的腈大规模制备胺的过程中发生严重爆炸。事故发生在还原1摩尔批次的1-甲基-3-（三氟甲基）-1 H-吡唑-5-腈的过程中。在用MeOH还原后，在反应混合物的分解阶段，通过爆轰破坏反应器。一位研究员因摔碎和被火焰烧伤而受到严重伤害。本案例研究详细描述了此事件，并讨论了如何预防类似事件。