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Smart, soft contact lens for wireless immunosensing of cortisol.
Science Advances ( IF 13.6 ) Pub Date : 2020-07-08 , DOI: 10.1126/sciadv.abb2891
Minjae Ku 1, 2 , Joohee Kim 1, 2 , Jong-Eun Won 2 , Wonkyu Kang 3 , Young-Geun Park 1, 2, 4 , Jihun Park 1, 2, 4 , Jae-Hyun Lee 2, 5 , Jinwoo Cheon 2, 5, 6 , Hyun Ho Lee 3 , Jang-Ung Park 1, 2, 5
Affiliation  

Despite various approaches to immunoassay and chromatography for monitoring cortisol concentrations, conventional methods require bulky external equipment, which limits their use as mobile health care systems. Here, we describe a human pilot trial of a soft, smart contact lens for real-time detection of the cortisol concentration in tears using a smartphone. A cortisol sensor formed using a graphene field-effect transistor can measure cortisol concentration with a detection limit of 10 pg/ml, which is low enough to detect the cortisol concentration in human tears. In addition, this soft contact lens only requires the integration of this cortisol sensor with transparent antennas and wireless communication circuits to make a smartphone the only device needed to operate the lens remotely without obstructing the wearer’s view. Furthermore, in vivo tests using live rabbits and the human pilot experiment confirmed the good biocompatibility and reliability of this lens as a noninvasive, mobile health care solution.



中文翻译:

用于皮质醇无线免疫传感的智能软性隐形眼镜。

尽管用于监测皮质醇浓度的免疫测定和色谱法有多种方法,但传统方法需要笨重的外部设备,这限制了它们作为移动医疗保健系统的使用。在这里,我们描述了对软智能隐形眼镜的人体试点试验,用于使用智能手机实时检测眼泪中的皮质醇浓度。使用石墨烯场效应晶体管形成的皮质醇传感器可以测量皮质醇浓度,检测限为10 pg/ml,该值低到足以检测人类眼泪中的皮质醇浓度。此外,这种软性隐形眼镜只需将皮质醇传感器与透明天线和无线通信电路集成,使智能手机成为远程操作镜片而不遮挡佩戴者视线的唯一设备。此外,活体兔子的体内测试和人体试点实验证实了该镜片作为无创移动医疗解决方案的良好生物相容性和可靠性。

更新日期:2020-07-08
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