Prostate cancer (PCa) is one of the most common malignant tumors in the world. Thioredoxin interacting protein (TXNIP) is downregulated in a variety of human tumors and plays an important role in tumor suppression. However, the expression level and biological functions of TXNIP in PCa have not been identified yet. Therefore, this study aims to investigate the expression and biological functions of TXNIP in PCa. We reported that the expression of TXNIP was significantly decreased in PCa and associated with clinicopathological features. Overexpression of TXNIP could significantly inhibited PC‐3 cells proliferation, migration, invasion, and glucose uptake. Additionally, overexpression of TXNIP could remarkably block cell cycle in the G0/G1 phase and promoted cell apoptosis. Furthermore, TXNIP expression correlated inversely with GLUT1 expression in PCa. Taken together, our results for the first time revealed that TXNIP was decreased in PCa. Moreover, TXNIP might act as a tumor suppressor of PCa and correlated with tumor occurrence and development. Our findings cast a new light on better understanding the occurrence and development of PCa and indicated that TXNIP might be favorable for PCa molecular target therapy.

中文翻译：

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硫氧还蛋白相互作用蛋白 (TXNIP) 在人类前列腺癌中充当肿瘤抑制因子。

前列腺癌（PCa）是世界上最常见的恶性肿瘤之一。硫氧还蛋白相互作用蛋白 (TXNIP) 在多种人类肿瘤中下调，并在肿瘤抑制中发挥重要作用。然而，TXNIP 在 PCa 中的表达水平和生物学功能尚未确定。因此，本研究旨在研究TXNIP在PCa中的表达和生物学功能。我们报道 TXNIP 的表达在 PCa 中显着降低并与临床病理特征相关。TXNIP的过表达可以显着抑制PC-3细胞的增殖、迁移、侵袭和葡萄糖摄取。此外，TXNIP的过表达可以显着阻断G0/G1期的细胞周期并促进细胞凋亡。此外，TXNIP 表达与 PCa 中的 GLUT1 表达呈负相关。综上所述，我们的结果首次显示 PCa 中 TXNIP 降低。此外，TXNIP 可能作为 PCa 的肿瘤抑制因子并与肿瘤的发生和发展相关。我们的研究结果为更好地了解 PCa 的发生和发展提供了新的线索，并表明 TXNIP 可能有利于 PCa 分子靶向治疗。