Exposure to ultrasound combined with intravenous injection of microbubbles is a technique that can be used to temporarily disrupt the blood–brain barrier. Transcranial monitoring of cavitation can be done with one or more passive cavitation detectors (PCDs). However, the positioning of the PCDs relative to the cavitation site and the attenuation of these signals by the skull are two sources of error in the quantification of cavitation activity. The aim of this study was to evaluate in vitro the amplitude variation of cavitation signals that can be expected for an excised porcine skull model. The variation caused by the relative positioning of the PCD with respect to the cavitation site was quantified. A position-based correction of the signal amplitude was evaluated. Pig skull samples were used to assess variation in signal amplitude caused by bone. The overall coefficient of variation of the signals owing to these measurement biases was estimated at 30.8%.

暴露于超声结合静脉注射微泡是一种可用于暂时破坏血脑屏障的技术。空化的经颅监测可以使用一个或多个被动空化检测器 (PCD) 来完成。然而，PCD 相对于空化位点的定位和颅骨对这些信号的衰减是空化活动量化中的两个误差来源。本研究的目的是评估体外切除的猪头骨模型可以预期的空化信号的幅度变化。由 PCD 相对于空化位点的相对定位引起的变化被量化。评估了基于位置的信号幅度校正。猪头骨样本用于评估由骨骼引起的信号幅度变化。由于这些测量偏差，信号的总体变异系数估计为 30.8%。