A tablet microstructure, especially the porosity, is a crucial parameter that influences the mechanical properties. Herein, tablet subdivisions were studied as a function of tablet porosity. The tablets were manufactured in the presence of different diluents, namely microcrystalline cellulose, Ludipress®, or lactose monohydrate. Furthermore, the addition of Camphor was investigated, which was thereafter sublimated with a view of obtaining tablets having varying degrees of porosity. Microstructural assays were correlated to the subdivision performance. The increase in porosity reduced the hardness and increased the tablet friability, adversely impacting the subdivision. For all the excipients, an increase in relative porosity >90% represented the threshold level from which an inadequate subdivision occurred. The increase in tablet porosity led to a reduction in mechanical resistance, which, combined with a heterogeneous and discontinuous distribution of pores within the matrix, resulted in poor subdivision results. Controlling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

片剂的微结构，特别是孔隙率，是影响机械性能的关键参数。本文中，研究了片剂细分作为片剂孔隙率的函数。片剂是在不同的稀释剂（即微晶纤维素，Ludipress？或乳糖一水合物）存在下生产的。此外，研究了樟脑的添加，其后出于获得具有不同孔隙度的片剂的观点而升华。微观结构测定与细分性能相关。孔隙率的增加降低了硬度并增加了片剂的脆性，对细分产生了不利影响。对于所有的赋形剂，相对孔隙率的增加> 90％表示阈值水平，从该阈值水平开始细分不足。片剂孔隙率的增加导致机械阻力的降低，再加上基质内孔隙的不均匀分布和不连续分布，导致细分效果不佳。当设计具有细分目的的片剂时，控制片剂的孔隙率是重要的考虑因素。