As a platform chemical with various applications, succinic acid (SA) is currently produced by petrochemical processing from oil-derived substrates such as maleic acid. In order to replace the environmental unsustainable hydrocarbon economy with a renewable environmentally sound carbohydrate economy, a bio-based SA production process has been developed during the past two decades. In this review, recent advances in the valorization of solid organic wastes including mixed food waste, agricultural waste and textile waste for efficient, green and sustainable SA production have been reviewed. Firstly, the application, market and key global players of bio-SA are summarized. Then achievements in SA production by several promising yeasts including Saccharomyces cerevisiae and Yarrowia lipolytica are detailed, followed by calculation and comparison of SA production costs between oil-based substrates and raw materials. Lastly, challenges in engineered microorganisms and fermentation processes are presented together with perspectives on the development of robust yeast SA producers via genome-scale metabolic optimization and application of low-cost raw materials as fermentation substrates. This review provides valuable insights for identifying useful directions for future bio-SA production improvement.

作为具有多种应用的平台化学品，琥珀酸（SA）当前是通过石油化学处理从石油衍生的基质（例如马来酸）中生产的。为了用可再生的对环境无害的碳水化合物经济代替环境不可持续的碳氢化合物经济，在过去的二十年中已经开发了基于生物的SA生产工艺。在这篇综述中，综述了固体有机废弃物（包括混合食品废弃物，农业废弃物和纺织废弃物）的增值方法，以实现高效，绿色和可持续的SA生产。首先，总结了生物SA的应用，市场和全球主要参与者。通过几个有前途的酵母包括SA生产然后成就酿酒酵母和脂耶氏酵母详细介绍，然后计算和比较油基基材和原材料之间的SA生产成本。最后，提出了工程微生物和发酵过程中的挑战，以及通过基因组规模的代谢优化和低成本原料作为发酵底物的应用来发展强大的酵母SA生产者的观点。这篇综述提供了宝贵的见解，可用于确定未来生物SA生产改进的有用方向。