We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria.

我们通过将溶菌酶吸附到金纳米颗粒上而获得的，基于斑驳的等离激元胶体的自限组装的抗菌纳米材料。在几百纳米内选择组件尺寸的可能性允许在从可见光到近红外的宽频率范围内调节其光学响应。我们还证明了催化活性的聚集依赖性调节，这导致适当尺寸的组件的抗菌性能增强。对这种纳米材料的结构，光学性质和生物活性的全面控制为开发新型抗菌纳米酶铺平了道路，并有望在治疗多药耐药细菌中得到应用。