The YOUth cohort study is a unique longitudinal study on brain development in the general population. As part of the YOUth study, 2000 children will be included at 8, 9 or 10 years of age and planned to return every three years during adolescence. Magnetic resonance imaging (MRI) brain scans are collected, including structural T1-weighted imaging, diffusion-weighted imaging (DWI), resting-state functional MRI and task-based functional MRI. Here, we provide a comprehensive report of the MR acquisition in YOUth Child & Adolescent including the test-retest reliability of brain measures derived from each type of scan. To measure test-retest reliability, 17 adults were scanned twice with a week between sessions using the full YOUth MRI protocol. Intraclass correlation coefficients were calculated to quantify reliability. Global brain measures derived from structural T1-weighted and DWI scans were reliable. Resting-state functional connectivity was moderately reliable, as well as functional brain measures for both the inhibition task (stop versus go) and the emotion task (face versus house). Our results complement previous studies by presenting reliability results of regional brain measures collected with different MRI modalities. YOUth facilitates data sharing and aims for reliable and high-quality data. Here we show that using the state-of-the art YOUth MRI protocol brain measures can be estimated reliably.

YOUTH队列研究是有关普通人群大脑发育的独特纵向研究。作为YOUTH研究的一部分，将包括2000名8岁，9岁或10岁的儿童，并计划在青春期每三年返回一次。收集磁共振成像（MRI）脑部扫描，包括结构T1加权成像，扩散加权成像（DWI），静止状态功能MRI和基于任务的功能MRI。在这里，我们提供了青少年儿童和青少年获得MR的综合报告，包括从每种扫描类型得出的脑测验的重测信度。为了测量重测的可靠性，使用完整的YOUTH MRI方案在每个疗程之间每周扫描17名成人两次。计算类内相关系数以量化可靠性。从T1加权结构和DWI扫描得出的全局脑测量结果是可靠的。静息状态下的功能连接具有中等程度的可靠性，并且对于抑制任务（停止与行走）和情绪任务（面部与房屋）的大脑功能均具有一定的可靠性。我们的研究结果通过展示采用不同MRI方式收集的区域性大脑测量结果的可靠性结果，对以前的研究进行了补充。YOUTH促进了数据共享，并致力于获得可靠和高质量的数据。在这里，我们表明，使用最新的YOUTH MRI协议，可以可靠地估算大脑测量结果。我们的研究结果通过展示采用不同MRI方式收集的区域性大脑测量结果的可靠性结果，对以前的研究进行了补充。YOUTH促进了数据共享，并致力于获得可靠和高质量的数据。在这里，我们表明，使用最新的YOUTH MRI协议，可以可靠地估算脑部测量结果。我们的研究结果通过展示采用不同MRI方式收集的区域性大脑测量结果的可靠性结果，对以前的研究进行了补充。YOUTH促进了数据共享，并致力于获得可靠和高质量的数据。在这里，我们表明，使用最新的YOUTH MRI协议，可以可靠地估算脑部测量结果。