当前位置: X-MOL 学术Biochimie › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.
Biochimie ( IF 3.9 ) Pub Date : 2020-07-08 , DOI: 10.1016/j.biochi.2020.07.001
Isabelle Dugail 1 , Ez-Zoubir Amri 2 , Nicolas Vitale 3
Affiliation  

It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.



中文翻译:

严重COVID-19中肥胖症的高患病率:对患者分层的可能联系和观点。

显而易见的是,除了衰老和各种炉膛病态之外,体重过重,尤其是肥胖是COVID-19感染严重程度的主要危险因素。有趣的是,SARS-CoV-2的受体是ACE2,它是血管紧张素受体家族的成员,具有相对较大的组织分布。该观察结果可能解释了人类患者所描述的多种症状。脂肪组织还表达ACE2,表明脂肪细胞可能被SARS-CoV-2感染。在这里,我们讨论了脂肪组织对感染严重程度的一些潜在贡献,并提出了肥胖患者代谢表型的某些方面,以帮助对具有严重疾病高风险的个体进行分层。

更新日期:2020-07-08
down
wechat
bug