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Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.
Allergologia et Immunopathologia ( IF 1.8 ) Pub Date : 2020-07-08 , DOI: 10.1016/j.aller.2019.07.012
Azam Mohsenzadeh 1 , Masoud Movahedi 2 , Mohammad Saatchi 3 , Nima Parvaneh 2 , Mansoureh Shariat 2 , Asghar Aghamohammadi 2 , Mohammad Gharagozlou 2
Affiliation  

Introduction and Objectives

Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children’s Medical Center.

Patients

The present study was a registry-based study in which the data of 94 SSLRs patients registered in a two-year period were investigated. Confirmation of fever, rash, urticaria, arthralgia / arthritis and history of antibiotic consumption up to three weeks before were the criteria for the diagnosis.

Results

Fifty-one (54 %) patients were male with mean age of 56 ± 30 months and there was no significant difference in the age of the two genders. The mean onset of symptoms before hospitalization were 3.8 ± 2.7 days (1–14 days); this mean was significantly higher in males than in females (4.6 ± 2.9 versus 2.9 ± 1.7 days, P-value = 0.003). Among antibiotics, Co-amoxiclav and Cefixime antibiotics had the most frequency by 31 % and 33 %, respectively as the most important incidence factor of SSLRs. The mean duration of consumption of culprit medications in the incidence of SSLRs was 5.6 ± 2.9 days with a range of 1–15 days.

Conclusions

This study showed that among the antibiotics, Co-amoxiclav and Cefixime are more prevalent and a review of prescribing these two antibiotics for the treatment of the children’s infections is essential if this finding is confirmed by other Iranian scholars.



中文翻译:

伊朗儿童的血清病样反应:转诊中心基于注册表的研究。

介绍和目标

考虑到到目前为止,尚未对伊朗转诊中心的血清病样反应患者(SSLR)进行全面研究,因此该研究旨在确定德黑兰儿童医学中心SSRL儿童的临床和实验室特征。

耐心

本研究是一项基于注册表的研究,其中调查了两年期间登记的94名SSLR患者的数据。确诊的标准是发烧,皮疹,荨麻疹,关节痛/关节炎以及直到三周前服用抗生素的历史。

结果

男性(51%)患者中,平均年龄为56±30个月,并且这两种性别的年龄均无显着差异。住院前症状的平均发作时间为3.8±2.7天(1-14天)。男性的这一平均值明显高于女性(4.6±2.9对2.9±1.7天,P值= 0.003)。在抗生素中,Co-amoxiclav和头孢克肟抗生素的频率最高,分别是SSLRs的最重要发生因素,分别为31%和33%。SSLR发生中罪魁祸首药物的平均消费时间为5.6±2.9天,范围为1-15天。

结论

这项研究表明,在抗生素中,Co-amoxiclav和Cefixime更为普遍,如果其他伊朗学者证实了这一发现,则必须对处方这两种抗生素来治疗儿童感染进行审查。

更新日期:2020-07-08
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