Abstract

Precursors were synthesized for the first time for obtaining tritium-labeled Вос-Gly-Pro-DOPA, Вос-Gly-Pro-Srt, LА-Gly-Pro-DOPA, LА-Gly-Pro-Srt, Вос-Pro-DOPA, Вос-Pro-Srt, Вос-Gly-Pro-Dox, LА-Gly-Pro-Dox, Вос-Pro-Dox. Tritium is introduced by using dehydroproline derivatives N-protected by a tert-butyloxycarbonyl group or lauric acid. The suggested approach made it possible to obtain labeled compounds in high yield with high molar radioactivity. A new procedure is suggested for purification of water-insoluble compounds by solid-phase extraction.

中文翻译：

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All标记的多巴胺，5-羟色胺和阿霉素的脯氨酸衍生物的合成，它们都含有叔丁氧羰基或月桂酸

摘要

首次合成前体以获得obtaining标记的Вос-Gly-Pro-DOPA，Вос-Gly-Pro-Srt，LА-Gly-Pro-DOPA，LА-Gly-Pro-Srt，Вос-Pro-DOPA， Вос-Pro-Srt，Вос-Gly-Pro-Dox，LА-Gly-Pro-Dox，Вос-Pro-Dox。通过使用被叔丁氧羰基或月桂酸N-保护的脱氢脯氨酸衍生物引入introduced 。所提出的方法使得以高产率和高摩尔放射性获得标记化合物成为可能。建议通过固相萃取纯化水不溶性化合物的新方法。