Abstract

This manuscript reports oxidation of amitriptyline at the carbon nanocomposite ionic liquid electrode fabricated using multi-walled carbon nanotubes and the ionic liquid 1-octylpyridinium hexafluorophosphate. The surface morphology of the electrode was characterized by scanning electron microscopy. Differential pulse voltammetry was applied as an analytical procedure for the determination of the sub-micromolar concentration of amitriptyline. Different experimental parameters were optimized. Considering optimized conditions, the proposed electrode represented remarkable sensitivity toward determination of amitriptyline compared to other conventional electrodes and linearity in the range from 5 × 10^–8 to 9 × 10^–5 was obtained for amitriptyline with the detection limit of 1.9 × 10^–8 M. Cyclic voltammetry was applied to obtain information about the reaction mechanism and calculating some kinetic parameters. The oxidation process was irreversible and showed adsorption-controlled behavior. The method was successfully applied for the quantification of amitriptyline in pharmaceuticals forms.

中文翻译：

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碳纳米复合离子液体电极上阿米替林的测定

摘要

该手稿报道了阿米替林在使用多壁碳纳米管和离子液体1-辛基吡啶六氟磷酸盐制备的碳纳米复合离子液体电极上的氧化。电极的表面形态通过扫描电子显微镜表征。应用微分脉冲伏安法作为分析程序，以确定亚微摩尔浓度的阿米替林。优化了不同的实验参数。考虑到优化的条件，与其他常规电极相比，拟议的电极对阿米替林的测定具有显着的灵敏度，对于阿米替林，其检测限为1.9×10 ，线性范围为5×10 ^–8至9×10 ^–5–8M。应用循环伏安法获得有关反应机理的信息并计算一些动力学参数。氧化过程是不可逆的，并表现出吸附控制的行为。该方法已成功用于药物形式的阿米替林的定量。